Recombinant antibodies should be accessible to all.
A leading provider of custom antibody sequencing, engineering, production, and purification services, we serve biotech innovators across therapeutic, diagnostic, and research applications. Our mission is to deliver engineered confidence—ensuring every antibody we produce is built on scientific rigor, transparency, and fit-for-purpose quality.
Antibody Engineering Expertise
Confidence engineered into every antibody.
- Successful production of 200+ different antibody formats
- Specialization in complex constructs including bispecifics, scFvs, and fragments
- Collaborative approach to develop the antibody best suited to your needs
Tailored Solutions
Every process is tailored to your molecule—not the other way around
- Customized workflow, from design to purification, based on the unique characteristics of each antibody
- 45+ purification routes across a dozen platforms to elicit highly pure antibodies
Rigorous Quality Controls
Quality built in, not bolted on.
- Workflows designed with quality in mind, not just QC at the end
- Built in checks throughout the process to go beyond “good enough”
- SEC and CE-SDS included as standard practice
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Engineered recombinant antibodies developed for our reagents catalog
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Hybridomas sequenced
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Successful antibody humanization projects
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Different antibody formats produced
Custom Antibody Services: Sequencing
It starts with a sequence.
Knowing your hybridoma or antibody protein sequence is crucial for the security and continuation of your antibody production. Our antibody sequencing services include Next Generation Sequencing of hybridoma cells and de novo sequencing of purified antibody protein. Sequencing can be performed as a stand-alone activity, or as the first step toward antibody engineering and transient serum-free expression. Whether it is a hybridoma or purified monoclonal antibody protein, Vector Laboratories offers industry-leading sequencing services to help safeguard your invaluable antibody.
Why Sequence Your Antibodies?
- Protect against loss, contamination or genetic drift
- Secure your supply chain
- Enable antibody engineering and recombinant production
- Patent your antibody
Antibody Protein Sequencing Service
- Sequence from purified monoclonal antibody when hybridoma is not available
- Combines mass spectrometry with high accuracy de novo peptide sequencing and recombinant expression
Hybridoma Sequencing Service
- Novel NGS approach to high-throughput sequencing
- Identifies all heavy chain and light chain sequences and quantifies their relative abundance
- Compatible with any species and isotype
Our hybridoma sequencing method – The mRNA transcriptome is obtained from the hybridoma, and random hexamers are used to generate a cDNA library. This is fragmented and undergoes paired-end sequencing. The sequencing reads are assembled into contigs, from which antibody transcripts are identified based on homology.
Custom Antibody Services: Engineering
Engineered Confidence. Built Around Your Molecule.
Antibody engineering allows for the modification of antibodies to build molecules better suited for your application. Vector Laboratories utilizes a proprietary cloning system that enables the rapid reformatting of antibodies into almost any format. From isotype and species switching to humanization and multispecifics, we engineer confidence into every step.
Explore our royalty-free antibody engineering capabilities below.
Isotype
Switching
Switching
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Switching an antibody's isotype or subtype can tailor effector function, reduce the number of needed controls, or expand research capabilities. Our engineering service can deliver antibodies in a variety of isotypes and subtypes to meet your needs.
Species
Switching
Switching
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Also called chimerization, this process maintains the antigen-binding variable domains of the original antibody and combines them with the constant domain of a new species. These antibodies can be used for in vivo and in vitro research, as well as tools for assay development. We offer multiple species including human, mouse, rat, rabbit, hamster, dog, and more.
Fragments
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Fragments can offer an ideal alternative to full-length antibodies, as they enable better tissue penetration, reduce non-specific binding, and increase antibody stability and solubility. We can convert any antibody into a fragment, including single chain Fv (scFv), Fab or Fab2 formats. We have successfully manufactured more than 45 different fragment formats, as seen in our Periodic Table of Antibodies.
Engineered
Fc Domains
Fc Domains
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Engineering the Fc domain of an antibody can mediate effector function and extend serum half-life. We offer various Fc engineering options, including STR silencing from mAbsolve, to customize your antibody to suit your needs.
Humanization
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Antibody humanization involves the transfer of critical non-human amino acids onto a human antibody framework, reducing immunogenicity risk while preserving the binding activity of the parent antibody. Our Prometheus™ humanization service delivers humanized antibodies with strong manufacturability, enabling production scale-up for clinical use.
Multispecifics
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Multispecific antibodies can bind two or more distinct antigens or epitopes, enabling enhanced targeting, immune cell engagement, and functional flexibility in research and therapeutic development. Our expertise is best demonstrated by the 90+ different bispecific and multispecific formats we have successfully engineered and expressed. View them in our Periodic Table of Antibodies.
Periodic Table of Antibodies
The Periodic Table of Antibodies showcases the wide assortment of custom antibodies we have produced. These novel antibody formats demonstrate the lengths scientists are going to combine protein engineering with biology to generate efficacious drugs. From standard IgGs to antibody fragments, multispecifics, and Fc fusion proteins, these new formats help tailor binding and half-life to specific biological settings. Every antibody depicted in the table has been manufactured in- house using our proprietary cloning system.
View the Periodic table of Antibodies poster and explore 180+ different antibody formats.
Custom Antibody Services: Production
Scalable expression tailored to your molecule.
Vector Laboratories’ expression platforms rapidly produce high-quality, animal-free recombinant antibodies in HEK or CHO cells. By utilizing serum-free mammalian transient expression systems, our production services offer a faster, more affordable alternative to stable cell line generation. These robust platforms have proven success in manufacturing recombinant antibodies in any species, isotype, or format with high purity and low endotoxin levels.
Scalability matters, which is why we offer a microgram-to-gram range of expression capabilities. From small-scale production, perfect for lead discovery candidate selection, to large-scale production, our expression services are flexible to your needs.
HEXpress™
HEK Antibody Production
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Serum-free mammalian transient antibody expression system offering a faster, more affordable alternative to stable cell line generation, rapidly producing recombinant antibodies in HEK cells with high purity and low endotoxin levels.
CHXpress™
CHO Antibody Production
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Transient CHO production at milligram-to-gram scales for bridging the gap to stable CHO production, or for tackling challenging constructs. CHXpress enables therapeutic antibody developers to quickly manufacture and screen a group of antibodies before taking the time to generate stable cell lines for their most promising candidates.
FleXpress™
Antibody Production
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High-throughput, serum-free antibody production service offers the flexibility to rapidly express a large number of IgG antibodies at pilot scale.
